We are in control. Rational-based structural modifications of tetracycline derivatives that can act as selective inducers of the transactivating proteins rtTA-1/2 and rtTA-D have been carried out. These modifications led to a novel two-stage regulatory system in which two separate genes can be regulated by using the selective inducers 9-dipropylaminodoxycycline (1) and doxycycline (dox).
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Berens et al. (2006) studied this question.
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