Ophthalmic acid, a tripeptide isolated from calf lens This structure is very similar to that of glutathione (I; R=SH), and so the question naturally arises whether the two peptides are formed in vivo by the same route. H2N*CH(CO2H) * [CH2]2*CO *NH * CH(CH2R) - CO NH*CH2*CO2H (I) The synthesis of glutathione in liver extracts takes place in two stages, each catalysed by a separate enzyme (Snoke & Bloch, 1952; Snoke, Yanari & Bloch, 1953; Yanari, Snoke & Bloch, 1953): Glutamic acid + cysteine + ATP y-glutamyl cysteine + ADP + H3PO4 y-Glutamyl cysteine + glycine + ATP glutathione + ADP + H3PO4 (ATP, adenosine triphosphate; ADP, adenosine diphosphate).
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Cliffe et al. (1958) studied this question.
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