Key result
Systemic inflammation in rheumatoid arthritis drives increased cardiovascular risk through arterial stiffness and plaque destabilization.
Self-monitoring of blood pressure is highlighted as a significant strategy for managing and preventing hypertension-related cardiovascular complications.
Increased risk of Cardiovascular Disease (CVD) in patients with Rheumatoid Arthritis (RA) has been well established for decades and bolstered by countless studies since the 1950’s [1,2]. Numerous papers have explored the pathogenesis and have demonstrated that the systemic infl ammation caused in RA increases arterial stiffness, which may result from loss of elasticity and stenosis [3,4]. The infl ammation also impairs cholesterol effl ux and leads to destabilization of coronary plaque, increasing the risk of rupture and infarction [5,6]. Studies have further demonstrated that active RA causes an imbalance in the dilatation and vasoconstriction of the endothelium, and enhanced residence of reactive oxygen species and proinfl ammatory factors within the endothelial walls, leading to barrier permeability and leakage of infl ammatory mediators into the Cardiovascular (CV) tissue [7,8].
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A 2021 study conducted a review in Rheumatoid arthritis and cardiovascular disease. Systemic inflammation in rheumatoid arthritis was evaluated on Cardiovascular disease risk, arterial stiffness, and plaque destabilization. Systemic inflammation in rheumatoid arthritis increases cardiovascular disease risk through arterial stiffness, impaired cholesterol efflux, plaque destabilization, and endothelial dysfunction.
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