Gardner's syndrome, colon cancer, and sarcoma

Soft tissue involvement is a major component of Gardner's syndrome. While these are frequently skin inclusion cysts, some patients exhibit fibrous dysplasias. These can vary from severe fibrosis, frequently intra‐abdominal and causing bowel obstruction, to desmoid tumors and fibrosarcomas, both of which can be progressive and life threatening. This aspect of the syndrome is poorly understood, but must be carefully evaluated in selecting treatment for the associated polyposis coli.