Polymer-caged nanobins (PCNs) that can undergo Cu(I)-catalyzed click reactions enable the combination of GdIII magnetic resonance imaging (MRI) contrast agents and an anticancer drug (gemcitabine, GMC) into a single theranostic platform (see picture). The resulting gadolinium(III)-conjugated, GMC-loaded PCNs (GdIII–PCNGMC) exhibit a significantly superior performance in r1 relaxivity, drug uptake, and pH-sensitive drug release.
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Lee et al. (2010) studied this question.
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