Why the study?
Does deep sedation with propofol and remifentanil allow safe dental treatment in a patient with Down syndrome and Eisenmenger syndrome?
Does deep sedation with propofol and remifentanil allow safe dental treatment in a patient with Down syndrome and Eisenmenger syndrome?
Intravenous deep sedation with propofol and remifentanil via target-controlled infusion can be safely used for dental treatment in patients with Down syndrome and Eisenmenger syndrome.
Supports sedation feasibility in this high-risk case; hypothesis-generating and requires prospective validation.
Eisenmenger syndrome (ES) is characterized by pulmonary arterial hypertension and right-to-left shunting. The signs and symptoms of ES include cyanosis, shortness of breath, fatigue, hemoptysis, and sudden death. In patients with ES, it is important that the systemic and pulmonary circulations be properly distributed and maintained. General dental treatment is not known to be particularly dangerous. To control pain and anxiety, local anesthetics without epinephrine are usually recommended. However, in cases of difficulty of cooperation, general anesthesia for dental treatment makes the condition worse. In the present case, intravenous deep sedation with propofol and remifentanil was administered for behavioral management during dental treatment successfully.
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In et al. (2016) studied this question.
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