Answers are grounded in this paper and cite their sources.
For any organism to be pathogenic it must be able to fulfil certain criteria: (1) adhere to the host; (2) grow within the host; (3) produce damage to the host locally or systemically and either directly or indirectly; (4) avoid the host's defence mechanisms long enough to cause disease. If any one of these characteristics is lacking, the organism will not be pathogenic.
No takes yet. Share an insight, caveat, or question.
C. W. I. Douglas (1994) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: