Why the study?
Scrub typhus is uncommon in newborns and presents with atypical symptoms, where untimely diagnosis and treatment can lead to a prolonged and potentially fatal course.
Metagenomic next-generation sequencing can rapidly and accurately diagnose pathogens in neonatal scrub typhus, aiding precise treatment.
Supports mNGS for rapid neonatal scrub typhus diagnosis; leaves open validation in larger cohorts.
Scrub typhus, an acute zoonotic disease from Orientia tsutsugamushi , is uncommon in newborns and presents atypical symptoms. Untimely diagnosis and treatment can lead to a prolonged and potentially fatal course. Early diagnosis and treatment are essential for better patient outcomes. Metagenomic next‐generation sequencing can rapidly and accurately diagnose pathogens, aiding precise treatment.
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Hu et al. (2025) studied this question.
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