Why the study?
Little is known regarding the effects of unfractionated heparin and bivalirudin on liver and kidney function in patients undergoing coronary angiography with or without percutaneous coronary intervention.
Does bivalirudin compared to unfractionated heparin affect liver and renal function in patients with coronary artery disease undergoing coronary angiography with or without PCI?
Population
134 consecutive patients (40-89 years-old) with CAD undergoing CAG with or without PCI
Comparison
Bivalirudin vs unfractionated heparin (UFH)
Authors
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Bivalirudin may better preserve renal function than UFH during CAG/PCI; leaves open whether this affects outcomes in randomized trials.
Does bivalirudin compared to unfractionated heparin affect liver and renal function in patients with coronary artery disease undergoing coronary angiography with or without PCI?
Bivalirudin may better preserve renal function compared to UFH in CAD patients undergoing CAG/PCI, particularly those with moderate-to-severe CKD, though UFH may be associated with less liver damage.
Jia et al. (2021) studied this question.
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