Severe Hepatitis in a Patient Taking Cetirizine

Letters17 July 2001Severe Hepatitis in a Patient Taking CetirizineMakoto Watanabe, MD, Naruaki Kohge, MD, and Takekazu Kaji, MDMakoto Watanabe, MDShimane Medical University; Izumo 693-8501, Japan (Watanabe, Kohge, Kaji)Search for more papers by this author, Naruaki Kohge, MDShimane Medical University; Izumo 693-8501, Japan (Watanabe, Kohge, Kaji)Search for more papers by this author, and Takekazu Kaji, MDShimane Medical University; Izumo 693-8501, Japan (Watanabe, Kohge, Kaji)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-2-200107170-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:A 23-year-old man with jaundice and general malaise was admitted to our hospital on 24 April 2000. He was not an alcoholic or an intravenous drug user. He had been taking cetirizine, 10 mg/d, since July 1999 for atopic dermatitis; he was taking no other drugs. Physical examination revealed jaundice without ascites or encephalopathy. Laboratory tests showed a serum total bilirubin level of 99 µmol/L (5.8 mg/dL), a direct bilirubin level of 3.4 mg/dL, an aspartate aminotransferase level of 28.80 µkat/L (1728 IU/L), an alanine aminotransferase level of 41 250 nkat/L (2475 IU/L), moderately elevated biliary enzyme ...Reference1. Clark S. Dangers of non-sedating antihistamines. Lancet. 1997;349:1268. [PMID: 9142059] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Makoto Watanabe, MD; Naruaki Kohge, MD; Takekazu Kaji, MDAffiliations: Shimane Medical University; Izumo 693-8501, Japan (Watanabe, Kohge, Kaji) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrugs and ToxinsCetirizine-induced hepatotoxicity: case series and review of the literatureCetirizineHepatic injury due to drugs, herbal compounds, chemicals and toxinsHepatotoxicidad por cetiricinaColestasis intrahepática grave asociada a la ingesta de cetiricinaHepatotoxicidad por ebastinaCetirizineSecond-Generation AntihistaminesRecurrent Acute Hepatitis Associated with Use of CetirizineIn Vitro Effects of Astaxanthin Combined With Ginkgolide B on T Lymphocyte Activation in Peripheral Blood Mononuclear Cells From Asthmatic SubjectsCetirizineAntihistamines (H1 receptor antagonists)Drug-induced liver diseaseAntihistamines (H1 receptor antagonists)Cetirizine 17 July 2001Volume 135, Issue 2 Page: 142-143 Keywords Alanine aminotransferase Antihistamines Bilirubin Drugs Liver Liver diseases Lymphocytes Prothrombin time Research laboratories Serum glutamic oxaloacetic transaminase ePublished: 17 July 2001 Issue Published: 17 July 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...