Why the study?
The study aimed to explore whether the association between maternal obesity and congenital heart defects is mediated by maternal pregestational diabetes.
Does maternal obesity increase the risk of congenital heart defects in mother-infant pairs?
Population
53,708 mother-infant pairs with deliveries between 2017 and 2019 in Shenzhen
Comparison
Maternal BMI categories: underweight, normal weight, overweight, and obesity
Design
Birth cohort study with mediation analysis
Authors
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Maternal obesity may raise CHD risk partly via PGDM; hypothesis-generating and requires prospective confirmation before guiding preconception care.
Does maternal obesity increase the risk of congenital heart defects in mother-infant pairs?
Maternal obesity is associated with an increased risk of congenital heart defects in offspring, an effect that is partially mediated by pregestational diabetes.
Wu et al. (2021) studied this question.
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