llar,15-Dihydroxy-9-ketoprost-5-enoic acid formed from prostaglandin Ez with the soluble fraction of guinea pig liver homogenates was shown to have the L configuration at C-15.By incubation of prostaglandin E2 labeled with deuterium (infer da) at C-15 and subsequent mass spectrometric analysis of the 1 lor, 15L-dihydroxy-9-ketoprost-5-enoic acid formed, it was found that the latter compound was not formed by direct reduction of the A13 double bond of prostaglandin E2.
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Hámberg et al. (1971) studied this question.
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