Comparison of Single-disc and Tube-dilution Techniques in Determining Antibiotic Sensitivities of Gram-negative Pathogens

Article1 January 1963Comparison of Single-disc and Tube-dilution Techniques in Determining Antibiotic Sensitivities of Gram-negative PathogensMARVIN TURCK, M.D., ROBERT I. LINDEMEYER, M.D., ROBERT G. PETERSDORF, M.D.MARVIN TURCK, M.D.Search for more papers by this author, ROBERT I. LINDEMEYER, M.D.Search for more papers by this author, ROBERT G. PETERSDORF, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-1-56 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSerious infections with Gram-negative pathogens have become an increasingly important problem in medical practice, particularly in debilitated hospitalized patients (1, 2). For example, at King County Hospital during the years 1960-61, the over-all incidence of Gram-negative bacteremia was greater than the combined incidence of bacteremia associated with the pneumococcus, staphylococcus, and streptococcus. The response of Gram-negative infections to antimicrobial therapy frequently has been unsatisfactory. While the outcome of these infections is often determined primarily by the patients' underlying disease rather than by the therapeutic regimen, antimicrobials remain the cornerstone of therapy. Therefore, a practical method of determining antimicrobial susceptibility of...References1. ROGERS DE: The changing pattern of life-threatening microbial disease. New Engl. J. Med. 261: 677, 1959. CrossrefMedlineGoogle Scholar2. FINLANDJONESBARNES MWFMW: Occurrence of serious bacterial infections since introduction of antibacterial agents. JAMA 170: 2188, 1959. CrossrefMedlineGoogle Scholar3. BAUERROBERTSKIRBY AWEWM: Single disc versus multiple disc and plate dilution techniques for antibiotic sensitivity testing, in Antibiotics Annual 1959-1960, Antibiotica, Inc., New York, 1960, p. 574. Google Scholar4. BAUERPERRYKIRBY AWDMWM: Single-disc antibiotic-sensitivity testing of staphylococci. Arch. Intern. Med. 104: 208, 1959. CrossrefGoogle Scholar5. PETERSDORFHOOKCURTINGROSSBERG RGEWJASE: The antimicrobial sensitivity of gram-negative pathogens. Bull. Johns Hopkins Hosp. 108: 48, 1961. MedlineGoogle Scholar6. TURCKFOURNIERPETERSDORF MMCRG: Laboratory and clinical studies of escherichia coli infections, in Antimicrobial Agents and Chemotherapy—1961, Braun-Brumfeld, Ann Arbor, 1962, pp. 113-120. Google Scholar7. SCHAUBFOLEYSCOTTBAILEY IGMKEGWR: Diagnostic Bacteriology, 5th Ed., The C. V. Mosby Company, St. Louis, 1958. Google Scholar8. KIRBYYOSHIHARASUNDSTEDTWARREN WMGKJ: Clinical usefulness of a single disc method for antibiotic sensitivity testing, in Antibiotics Annual 1956-1957, Antibiotica, Inc., New York, 1957, p. 892. Google Scholar9. ERICSSONSVARTZ-MALMBERG HG: Determination of bacterial sensitivity in vitro and its clinical evaluation. Antibiot. Chemother. (Basel) 6: 41, 1959. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Seattle, WashingtonFrom the Department of Medicine, University of Washington School of Medicine, and The King County Hospital, Seattle, Washington.Supported by training grant 2E 146 (C2) of the United States Public Health Service.Doctor Lindemeyer is a Trainee of the United States Public Health Service.Requests for reprints should be addressed to Robert G. Petersdorf, M.D., The King County Hospital System, 325 Ninth Avenue, Seattle 4, Washington. 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ANDERSON, M.D., RONALD H. SMITH, M.D, JAMES F. WALLACE, M.D., ROBERT G. PETERSDORF, M.D., F.A.C.P.Pharmaceutical Sciences—1963. Part IIBacteriology and Immune Response in Urinary Tract InfectionsObservations in the Therapy of Pyelonephritis 1 January 1963Volume 58, Issue 1Page: 56-65KeywordsAntimicrobialsBacteremiaChloramphenicolHospital medicineMedical servicesPathogensPneumococcusPseudomonas aeruginosaStaphylococcusStreptococcus Issue Published: 1 January 1963 PDF DownloadLoading ...