This review highlights the utility of voltage clamp fluorimetry in understanding the real-time conformational changes of mammalian Kv1 channels during gating.
VCF advances real-time Kv1 gating studies; leaves open clinical translation pending prospective validation.
VCF (voltage clamp fluorimetry) provides a powerful technique to observe real-time conformational changes that are associated with ion channel gating. The present review highlights the insights such experiments have provided in understanding Kv (voltage-gated potassium) channel gating, with particular emphasis on the study of mammalian Kv1 channels. Further applications of VCF that would contribute to our understanding of the modulation of Kv channels in health and disease are also discussed.
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Claydon et al. (2007) studied this question.
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