The effects of radiation on the functional vasculature of the hamster cheek pouch has been evaluated by isotopic techniques. The86 Rb extraction system has been used to measure blood flow, while51 Cr-labeled erythrocytes have been utilized to determine changes in blood volume. Modifications in these two parameters were determined by comparisons between irradiated and control pouches in the same animal. As early as 2 wk after irradiation, the isotope techniques indicated increases in blood flow and volume for doses of 2000 and 3000 rads. At later times, modification in both flow and volume were indicated with doses of 500, 2000, and 3000 rads. No change was observed after a dose of 1000 rads.
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J. W. Hopewell (1975) studied this question.