A controversy on HLA-G and B-cell malignancies?

Introduction The non-classical human lymphocyte antigen-G (HLA-G) is a potent suppressive molecule that impairs effector functions of immune cells belonging to the innate and the adaptive immune system. In physiological conditions HLA-G is restrictedly expressed but can be up-regulated in allogeneic situations, inflammations, and cancer [1]. HLA-G preferentially interacts with three