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June 1, 1987Anaesthesia

Should air‐oxygen replace nitrous oxide‐oxygen in general anaesthesia?

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Why the study?

Does compressed air-oxygen safely and cost-effectively replace nitrous oxide-oxygen in general anaesthesia?

Population

378 patients undergoing general anaesthesia

Comparison

Compressed air-oxygen mixtures vs Nitrous oxide-oxygen mixtures

Design

Other

Authors

HMH. MoseleyUniversity of the West IndiesAKAjay KumarChandigarh UniversityKSK.B. ShankarInstitute of Electronics

Discussion

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Implication

May support compressed air-oxygen as lower-cost option without observed recovery or awareness issues; leaves open randomized confirmation before practice change.

Structured PICO

Does compressed air-oxygen safely and cost-effectively replace nitrous oxide-oxygen in general anaesthesia?

P
Population
378 patients undergoing general anaesthesia
I
Intervention
Compressed air-oxygen mixtures
C
Comparator
Nitrous oxide-oxygen mixtures
O
Outcome
Recovery time, awareness under anaesthesia, and cost

Compressed air-oxygen mixtures can safely replace nitrous oxide-oxygen in general anaesthesia while significantly reducing costs.

Cite This Study

Moseley et al. (1987) studied this question.

synapsesocial.com/papers/6a8518ed18016805cd0cca04https://doi.org/10.1111/j.1365-2044.1987.tb03084.x
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Inactivation of Methionine Synthase by Nitrous Oxide1980 · 108 citations
  2. 2Exposure to Nitrous Oxide and Neurologic Disease among Dental Professionals1982 · 86 citations
  3. 3Reactions of gases in solution. Part III. Some reactions of nitrous oxide with transition-metal complexes1968 · 188 citations
  4. 4Nitrous Oxide Inactivates Methionine Synthetase in Human Liver1982 · 88 citations