Embedding of Active Proteins and Living Cells in Redox‐Sensitive Hydrogels and Nanogels through Enzymatic Cross‐Linking

Redox-sensitive materials have received dramatically increasing interest over the past years.1 Disulfide cross-linked colloidal networks are particularly appealing, as they are rapidly reduced to thiols under the reductive environment inside cells, allowing the quantitative release of the payload incorporated within the particles.2 Moreover, disulfide cross-linked hydrogels as three-dimensional cell-culture scaffolds can be degraded under cytocompatible mild reductive conditions without affecting the vitality of the embedded cells.3