OBJECTIVE: The arthritogenic potential of the cationic outer surface proteins (Osp) from Borrelia burgdorferi was tested in rats. METHODS: Water-soluble Osps were prepared by butanol extraction and were administered by intraarticular injection. Tissue injury was assessed by scintigraphy and histology. RESULTS: A mild arthritis was seen in naive rats. Preimmunized animals had more severe, longer lasting bouts of inflammation. CONCLUSION: The Osps of Borrelia burgdorferi are potent arthritogens in rats. These immunodominant antigens may play a role in the development of Lyme arthritis in humans.
No takes yet. Share an insight, caveat, or question.
Gondolf et al. (1994) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: