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The diameter of RI-67 virus in infected HeLa culture material was about 109 mu (± 6 mu) determined by pseudo-velocity sedimentation experiments, 80-120 mu based on Gradacol membrane filtration and 90 mu (standard deviation ± 4 mu) shown by electron microscope measurement. Purified preparations of RI-67 and latent adenoid degenerative agent AD-6 contained numerous spherical bodies of uniform size and shape and also a few “doughnut” forms. The CF antigen of infected RI-67 culture fluid sedimented less rapidly than the virus and passed through Gradacol membranes which held back the virus.
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Hilleman et al. (1955) studied this question.