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In this paper the synthesis of methynolide ( 1 ), the aglycone of methymycin, a 12‐membered macrolide antibiotic is described. We have used the chiral C‐1 to C‐8 segment 10 which has been combined with the C‐9 to C‐13 segment 9 to form the carbon skeleton of methynolide. Cyclization of the seco ‐acid 14 has been accomplished by intramolecular esterification.
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Klaus Ditrich (1990) studied this question.
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