Phenytoin-like hypersensitivity associated with lamotrigine

function, whereas it has not in many patients with decreased renal function, despite high iodine loads f rom radiographic procedures. Allergic reactions to radiographic dyes are not uncommon, occurring in approximately 1% of patients.* However , these reactions are usually of the immediate hypersensitivity type (e.g., urticaria and flushing). In contrast, iododerma may be a delayed-type hypersensitivity reaction, although intradermal and patch testing and indirect immunofluorescence studies have been negative. In some studies, lymphocyte transformation tests with iodinated human serum albumin have been positive, suggesting that iodine acts as a hapten.10, 11 After recovery, patients should be instructed to avoid iodine in the diet, in medications, and in future radiographic studies.