Exfoliative Dermatitis Due to Phenobarbital With Fatal Outcome; Report of Two Cases

Case Reports1 January 1940EXFOLIATIVE DERMATITIS DUE TO PHENOBARBITAL WITH FATAL OUTCOME; REPORT OF TWO CASESUDO J. WILE, M.D., F.A.C.P., JOSEPH A. BENSON, M.D.UDO J. WILE, M.D., F.A.C.P.Search for more papers by this author, JOSEPH A. BENSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-7-1243 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPhenobarbital, chemically a white colorless substance, phenylethylbarbituric acid or phenylethylmalonylurea was first placed in the hands of clinicians in 1911 under the proprietary name of Luminal. Introduced as a sedative and hypnotic, its greatest success was in the treatment of epilepsy; and, at the present time, it is probably the most frequently prescribed sedative in modern medical practice.A few months after its introduction, Loewe1(1912) reported the first case of cutaneous reaction due to the ingestion of phenobarbital. He published his observations of three cases, each patient exhibiting a generalized macular eruption, without systemic reaction, the rash fading upon...Bibliography1. LOEWE S: Klinische Erfahrungen mit Luminal, Deutsch. med. Wchnschr., 1912, xlii, 947. CrossrefGoogle Scholar2. HEUBER E: Ein Fall von Luminalvergiftung mit tödlichem Ausgang, München. med. Wchnschr., 1919, lxvi, 1090-1091. Google Scholar3. WEBER FP: Morbilliform and bullous eruption with jaundice, from luminal, in choreic child, Brit. Jr. Child. Dis., 1925, xxii, 280-285. Google Scholar4. HAMILTONGEIGERROTH ESCWJH: Luminal poisoning with conjunctival residue, Illinois Med. Jr., 1926, xlix, 344-346. Google Scholar5. MENNINGER WC: Skin eruptions with phenobarbital, Jr. Am. Med. Assoc., 1928, xci, 14-18. CrossrefGoogle Scholar6. CHAVANYVANNIER JAPE: Toxidermie barbiturique à type d'erythème scarlatiniforme infiltré, Progres Med., 1929, xliv, 1685-1693. Google Scholar7. BRUNSTING LA: Dermatitis medicamentosa: idiosyncrasy to quinine, Phenolphthalein and phenobarbital, Proc. Staff Meet., Mayo Clin., 1932, vii, 618-620. Google Scholar8. MILLARD RJ: Three cases of luminal poisoning, Med. Jr. Australia, 1933, ii, 518. CrossrefGoogle Scholar9. HECKMANN M: Luminalkrankheit unter dem Bilde der Dermatitis exfoliativa mit tödlichem Ausgang, Ztschr. f. Kinderh., 1935, lvii, 358-360. CrossrefGoogle Scholar10. SCARLETTMACNAB EPDS: Poisoning from phenobarbital with report of a fatal case, and review of fatalities previously reported, Canad. Med. Assoc. Jr., 1935, xxxiii, 635-641. Google Scholar11. SWEITZERLAYMON SECW: Severe cutaneous reactions to barbiturates, Minnesota Med., 1937, xx, 92-96. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, Michigan*Received for publication November 5, 1938.Studies and contributions from the Department of Dermatology and Syphilology, University of Michigan Medical School, Service of Dr. Udo J. Wile. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited by5-Ethyl-5-Phenylbarbituric Acid 50-06-6Toxic epidermal necrolysisLyell's syndrome on a burns unitTOXIC EPIDERMAL NECROLYSISToxic Epidermal NecrolysisToxic epidermal necrolysisPLASTER CASTS IN ARTHRITISSENSITIVITY TO PHENOBARBITONEThe phenobarbital sensitivity syndromePOISONING BY BARBITURATES SUCCESS OF CONSERVATIVE TREATMENT 1 January 1940Volume 13, Issue 7Page: 1243-1249KeywordsDermatologyEpilepsyIngestionRashesSedatives ePublished: 1 December 2008 Issue Published: 1 January 1940 PDF downloadLoading ...