Stimulation of cell‐surface receptors that couple to phospholipase C to generate the second messenger inositol trisphosphate often evokes repetitive oscillations in cytosolic Ca 2+ . Signalling information is encoded in both the amplitude and frequency of the Ca 2+ spikes. Recent studies have revealed that the spatial profile of the oscillation also imparts signalling power; Ca 2+ microdomains near store‐operated CRAC channels in the plasma membrane and inositol trisphosphate‐gated channels in the endoplasmic reticulum both signal to distinct downstream targets. Spatial profiling therefore increases the transduction power of the universal oscillatory cytosolic Ca 2+ signal.
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Samanta et al. (2016) studied this question.
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