The immunoreactive human growth hormone content (IRHGH) of carcinomas of the bronchus and stomach has been measured by radioimmunoassay (RIA). Significant amounts were extractable from 7 of 18 bronchogenic tumors and from five of eight gastric tumors. Tumors containing the highest concentrations of the material tended to be anaplastic. The IRHGH from one gastric tumor was characterized further by gel filtration and polyacrylamide disc electrophoresis, and had the properties of monomeric HGH. The significance of these observations will be clarified further by studies on whether the material is synthesized or taken up by these neoplasms.
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Beck et al. (1972) studied this question.
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