535North Dearborn Street . . . Chicago, Ill. Cable Address . . . . "Medic, Chicago" Subscription price . . . . . Five dollars per annum in advance Contributors, subscribers and readers will find important information on the second advertising page following the reading matter SATURDAY, JANUARY 6, 1917 A STUDY OF CROSSED TOLERANCE FOR DRUGS The expression "crossed tolerance" has been employed to designate the altered susceptibility which subjects that have acquired a considerable degree of tolerance for one drug or poison may thereafter exhibit toward another potent substance. In certain instances this phenomenon is well recognized. A habitual drunkard, tolerant to large doses of alcohol, usually is noticeably resistant to the general anesthetics. It is not difficult to understand the occurrence of crossed tolerance in the case of drugs very closely related which act in essentially similar ways on the organism; but as the mechanism of habituation and increased resistance to drugs is little understood in all but
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A 1917 study studied this question.