PAX5-ELN oncoprotein promotes multistep B-cell acute lymphoblastic leukemia in mice

This is the authors' abstract. We don't add key points for this paper.

Significance Engineered mouse models of acute leukemia are critical to understanding the biological mechanisms by which a primary oncogene induces disease. While PAX5 fusion proteins are considered primary oncogenic events in B-ALL, their role in leukemia development is ill-known due to the lack of animal models. This report provides a novel and accurate in vivo model for B-ALL induced by PAX5-ELN fusion protein that establishes a preleukemic phase and recapitulates the key features of human disease, including acquired mutations in genes of the JAK/STAT and RAS/MAPK pathways. This study is of general interest, as it allows a better understanding of the biological mechanism by which an oncoprotein perturbs normal B-cell development and leads to pathological B-ALL.