Why the study?
Is hypertension associated with altered cardiac tissue content of atrial natriuretic factor in a rat model?
Population
Spontaneously hypertensive rats and Wistar-Kyoto controls; anesthetized, normovolemic Sprague-Dawley rats…
Comparison
Fresh atrial extracts from spontaneously… vs Fresh atrial extracts from Wistar-Kyoto control…
Design
Preclinical
Authors
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Suggests depleted atrial stores may sustain hypertension; hypothesis-generating for natriuretic factor dynamics in blood pressure control.
Is hypertension associated with altered cardiac tissue content of atrial natriuretic factor in a rat model?
Spontaneously hypertensive rats have reduced atrial content of natriuretic factor, suggesting that chronic release and increased blood levels may be involved in the generation and maintenance of hypertension.
Sonnenberg et al. (1983) studied this question.
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