Why the study?
Do missense mutations in the CACNA1H gene alter the function of human Cav3.2 channels?
Do missense mutations in the CACNA1H gene alter the function of human Cav3.2 channels?
Functional characterization of CACNA1H mutations supports its role as a susceptibility gene in complex idiopathic generalized epilepsy.
Supports CACNA1H as epilepsy susceptibility gene; leaves open clinical translation from animal models.
Heron and colleagues (Ann Neurol 2004;55:595-596) identified three missense mutations in the Cav3.2 T-type calcium channel gene (CACNA1H) in patients with idiopathic generalized epilepsy. None of the variants were associated with a specific epilepsy phenotype and were not found in patients with juvenile absence epilepsy or childhood absence epilepsy. Here, we introduced and functionally characterized these three mutations using transiently expressed human Cav3.2 channels. Two of the mutations exhibited functional changes that are consistent with increased channel function. Taken together, these findings along with previous reports, strongly implicate CACNA1H as a susceptibility gene in complex idiopathic generalized epilepsy.
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Khosravani et al. (2005) studied this question.
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