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Viral evasion of ISG20 underscores restriction diversity; leaves open self/non-self RNA discrimination mechanisms.
ISG20 is a broad-spectrum antiviral protein capable of specifically degrading viral RNA. Here, we examine the different strategies developed by viruses to evade ISG20-mediated restriction, shedding light on how this exonuclease distinguishes between self and non-self RNAs, and highlighting the many questions that remain unanswered.
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Zoladek et al. (2025) studied this question.
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