Why the study?
Does signal-averaged electrocardiography reveal atrial electrical abnormalities in patients with Brugada syndrome compared to normal controls and PAF patients?
Does signal-averaged electrocardiography reveal atrial electrical abnormalities in patients with Brugada syndrome compared to normal controls and PAF patients?
Patients with Brugada syndrome exhibit abnormal P wave durations on signal-averaged ECG that are intermediate between normal controls and patients with paroxysmal atrial fibrillation, suggesting an underlying atrial arrhythmogenic substrate.
Suggests an underlying atrial arrhythmogenic substrate in Brugada syndrome; leaves open whether.
BACKGROUND: Ventricular fibrillation and atrial fibrillation are well-known arrhythmias in patients with Brugada syndrome. This study evaluated the characteristics of the atrial arrhythmogenic substrate using the signal-averaged electrogram (SAECG) in patients with Brugada syndrome. METHODS: SAECGs were performed during normal sinus rhythm in 23 normal volunteers (control group), 21 patients with paroxysmal atrial fibrillation (PAF; PAF group), and 21 with Brugada syndrome (Brugada group). RESULTS: The filtered P wave duration (fPd) in the control, Brugada, and PAF groups was 113.9±12.9ms, 125.3±15.0ms, and 137.1±16.3ms, respectively. The fPd in the PAF group was significantly longer compared to that in the control and Brugada groups (p<0.05). The fPd in the Brugada group was significantly longer than that in the control group (p<0.05) and significantly shorter than that in the PAF group (p<0.05). CONCLUSION: Patients with Brugada syndrome had abnormal P waves on the SAECG. The abnormal P waves on the SAECG in Brugada syndrome patients may have intermediate characteristics between control and PAF patients.
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Nagamoto et al. (2017) studied this question.
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