Why the study?
Is sinus node dysfunction associated with Brugada syndrome?
Is sinus node dysfunction associated with Brugada syndrome?
This review highlights that sinus node dysfunction is a recognized concomitant disorder in Brugada syndrome, pointing to a broader arrhythmogenic disorder beyond the ventricles.
Supports SND evaluation in BrS; leaves open whether it refines risk stratification or management.
Brugada syndrome (BrS) is a well-known catastrophic disease first reported in 1992 by the Brugada brothers. Ventricular fibrillation (VF) is an essential arrhythmia in BrS. An association between BrS and atrial tachyarrhythmias is not uncommon. However, sinus node dysfunction (SND) associated with BrS has not been well discussed. In this review, we focus on the association between BrS and SND. Based on previous reports describing clinical, epidemiological, and genetic evidence, SND is not a rare concomitant disorder in BrS. BrS may be a multiple conduction or arrhythmogenic disorder including not only the His-Purkinje system and right ventricle, but also the sinus node and atrium, derived from ion channel mutations.
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Hayashi et al. (2018) studied this question.
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