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Litten ( 1 ) observed in 1881 that temporary occlusion of the renal artery in dog and rabbit for 11/2 to 2 hours was followed by tubular ne- crosis. In 1926 McEnery, Meyer and Ivy (2) clamped the blood vessels of both kidneys in dogs for periods of 30 minutes to 1 hour. This led to an increase in BUN 2 and some animals died in uremia. Recently, Emmel (3) described
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Koletsky et al. (1947) studied this question.
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