Why the study?
Does head-up bed treatment alter the hemodynamic response to postural changes and angiotonin in a patient with orthostatic hypotension?
Does head-up bed treatment alter the hemodynamic response to postural changes and angiotonin in a patient with orthostatic hypotension?
Head-up bed treatment for orthostatic hypotension restored normal renal hemodynamic responses to postural changes and angiotonin in a single patient.
Head-up bed treatment normalized responses in one orthostatic hypotension case; leaves open generalizability and requires prospective trials.
Our purpose in the present report is to describe observations on the effects of postural changes and angiotonin injections on arterial pressure, pulse rate and renal hemodynamics in a patient who suffered from orthostatic hypotension and who was effectively treated by the head-up bed described by MacLean and Allen.¹Briefly stated, before treatment the patient responded to a tilt of 60 degrees by syncope, decreased arterial pressure and renal blood flow. Injection of angiotonin greatly increased the blood pressure and renal blood flow. This effect of angiotonin contrasts sharply with the renal ischemia which accompanies its pressor action in normotensive subjects. After two months' treatment with the head-up bed a tilt to 60 degrees did not cause syncope, and renal blood flow was increased in spite of a transient decrease of arterial pressure. The injection of angiotonin at this time resulted in its characteristic pressor and renal vasoconstrictor effects.
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Corcoran et al. (1942) studied this question.
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