The Effects of Shock on the Kidney

Article1 April 1948THE EFFECTS OF SHOCK ON THE KIDNEYDONALD D. VAN SLYKEDONALD D. VAN SLYKESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-28-4-701 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe type of "shock" here discussed is the condition, caused by hemorrhage, burns, trauma, dehydration, or other injury, in which there is an inadequate volume of blood to fill the vascular bed. The visible effects in man, prostration, cold perspiration, bloodless or cyanotic skin, etc., are familiar. It appears that similar renal effects can result from a period of peripheral circulatory failure due, not to decreased blood volume, but to cardiac failure, or to pooling of blood in part of the vascular bed; but the present discussion is limited to conditions of shock in which decreased volume of the circulating...Bibliography1. VAN SLYKEPHILLIPSHAMILTONARCHIBALDDOLEEMERSONSTANLEYBECKEROSSERMAN DDRAPBRMVPKEGWHF: Effect of shock on the kidney, Trans. Assoc. Am. Phys., 1944, lviii, 119. Google Scholar2. LAUSONBRADLEYCOURNAND HDSEA: The renal circulation in shock, Jr. Clin. Invest., 1944, xxiii, 381. CrossrefGoogle Scholar3. PHILLIPSDOLEHAMILTONEMERSONARCHIBALDVAN SLYKE RAVPPBKRMDD: Effects of acute hemorrhagic and traumatic shock on renal function of dogs, Am. Jr. Physiol., 1946, cxlv, 314. CrossrefGoogle Scholar4. TRUETABARCLAYDANIELFRANKLINPRICHARD JAEPMKJML: Renal pathology in the light of recent neurovascular studies, Lancet, 1946, ii, 237; Studies of the renal circulation, 1947, Blackwell Scientific Publications, Oxford, England. CrossrefGoogle Scholar5. GREENCOSBYLEWIS HDRSRN: Modification of blood flow in skin and muscle of dogs in hemorrhagic shock, Fed. Proc., 1942, Part II, i, 32. Google Scholar6. LUCKÉ B: Lower nephron nephrosis, Mil. Surg., 1946, xcix, 371. Google Scholar7. MALLORY TB: Hemoglobinuric nephrosis in traumatic shock, Am. Jr. Clin. Path., 1947, xvii, 427. CrossrefGoogle Scholar8. BADENOCHDARMADY WWEM: The effects of temporary occlusion of the renal artery in rabbits and its relationship to traumatic uraemia, Jr. Path. and Bact., 1947, lix, 79. CrossrefGoogle Scholar9. DARMADYSIDDONSCORSONLANGTONVITEKBADENOCHSCOTT EMAHTCCDZAWJC: Traumatic uremia. Report on 8 cases, Lancet, 1944, ii, 809. DARMADY, E. M.: Renal anoxia and the traumatic uraemia syndrome, British Jr. Surg., 1947, xxxiv, 262. CrossrefGoogle Scholar10. MAEGRAITHADELAIDEHAVARDPARSONS BGMBREDS: Renal syndrome of wide distribution induced possibly by renal anoxia, Lancet, 1945, ii, 293. CrossrefGoogle Scholar11. CORCORANPAGE ACIH: Genesis of crush syndrome, Jr. Lab. and Clin. Med., 1945, xxx, 351. Google Scholar12. RICHARDS AN: Direct observations of change in function of the renal tubule caused by certain poisons, Trans. Assoc. Am. Phys., 1929, xliv, 64. Google Scholar13. BYWATERS EG: Ischemic muscle necroses. Crushing injury, traumatic edema, the crush syndrome, traumatic anuria, compression syndrome: a type of injury seen in air raid casualties following burial beneath debris, Jr. Am. Med. Assoc., 1944, cxxiv, 1103. (This review provides references to earlier work of Bywaters and his collaborators.) CrossrefGoogle Scholar14. FISHBERG AM: Hypertension and nephritis, 4th Ed., 1939, p. 55 et seq., Lea and Febiger, Philadelphia. Google Scholar15. VAN SLYKERHOADSHILLERALVING DDCPAA: The relationship of the urea clearance to the renal blood flow, Am. Jr. Physiol., 1934, cx, 387. CrossrefGoogle Scholar16. ROGERS L: Further work on the reduction of the alkalinity of the blood in Asiatic cholera, and sodium bicarbonate injection in the prevention of uremia, Ann. Trop. Med. and Parasit., 1916-17, x, 129. Bowel diseases in the tropics, 1921, London. Google Scholar17. MARSHALLCRANE EKMM: The influence of temporary closure of the renal artery on the amount and composition of the urine, Am. Jr. Physiol., 1923, lxiv, 387. CrossrefGoogle Scholar18. SCARFFKEELE RWLA: The effects of temporary occlusion on the renal circulation of the rabbit, Brit. Jr. Exper. Path., 1943, xxiv, 147. Google Scholar19. PHILLIPSHAMILTON RAPB: Effects of renal ischemia in dogs. II. Effects of 20, 60 and 120 minutes of renal cachemia on glomerular and tubular function, Am. Jr. Physiol., 1948, in press. CrossrefGoogle Scholar20. HAMILTONPHILLIPSHILLER PBRAA: Effects of renal ischemia. I. Duration of renal ischemia required to produce death in uremia, Am. Jr. Physiol., 1948, in press. CrossrefGoogle Scholar21. VAN SLYKEHILLERMILLER DDABF: The clearance, extraction percentage and estimated filtration of sodium ferricyanide in the mammalian kidney. Comparison with inulin, creatinine, and urea, Am. Jr. Physiol., 1935, cxiii, 611. CrossrefGoogle Scholar22. WARRENBRANNON JVES: A method of obtaining renal venous blood in unanesthetized persons, with observations on the extraction of oxygen and sodium para-amino hippurate, Science, 1944, c, 108. BRADLEY, S. E., and CURRY, J., Cited by W. Goldring and H. Chasis in Hypertension and hypertensive disease, 1944, Publication of The Commonwealth Fund, New York. CrossrefGoogle Scholar23. DOLEEMERSONPHILLIPSHAMILTONVAN SLYKE VPJRAPDD: The renal extraction of oxygen in experimental shock, Am. Jr. Physiol., 1946, cxlv, 337. CrossrefGoogle Scholar24. HAMILTONCOLLINS ASDA: The homeostatic rôle of a renal humoral mechanism in hemorrhage and shock, Am. Jr. Physiol., 1942, cxxxvi, 275. CrossrefGoogle Scholar25. BAHNSON HT: Rôle of the kidneys in the resistance of rats to hemorrhage, Am. Jr. Physiol., 1943, cxl, 416. CrossrefGoogle Scholar26. PAGE IH: The occurrence of a vasoconstrictor substance in blood during shock induced by trauma, hemorrhage and burns, Am. Jr. Physiol., 1943, cxxxix, 386. CrossrefGoogle Scholar27. DEXTERFRANKHAYNESALTSCHULE LHAFWMD: Traumatic shock. VI. The effect of hemorrhagic shock on the concentration of renin and hypertensinogen in the plasma in unanesthetized dogs, Jr. Clin. Invest., 1943, xxii, 847. CrossrefGoogle Scholar28. CORCORANTAYLORPAGE ACRDIH: Immediate effects on renal function of the onset of shock due to partially occluding limb tourniquets, Ann. Surg., 1944, cxviii, 871. Google Scholar29. SHORRZWEIFACHFURCHGOTT EBWRF: On the occurrence, sites and modes of origin and destruction, of principles affecting the compensatory vascular mechanisms in experimental shock, Science, 1945, cii, 489. CrossrefGoogle Scholar30. BAEZZWEIFACHSHORR SBWE: Hepato-renal factors in circulatory homeostasis. II. Disappearance of hepatic vaso-depressor material following intravenous administration, Proc. Soc. Exper. Biol. and Med., 1947, lxiv, 154. CrossrefGoogle Scholar31. CHAMBERSZWEIFACH RBW: Blood-borne vasotrophic substances in experimental shock, Am. Jr. Physiol., 1947, cl, 239. CrossrefGoogle Scholar32. VAN SLYKEEVANS KKEI: The paradox of aciduria in the presence of alkalosis caused by hypochloremia, Ann. Surg., 1947, cxxvi, 545. CrossrefGoogle Scholar33. VAN SLYKEEVANS KKEI: The regulation of parenteral water and salt administration, Ann. Surg., 1948, in press. Google Scholar34. REIMANNCHANGCHULIUOU HAGCLWPYY: Asiatic cholera. Clinical study and experimental therapy with streptomycin, Am. Jr. Trop. Med., 1946, xxvi, 631. CrossrefGoogle Scholar35. PHILLIPSVAN SLYKEDOLEEMERSONHAMILTONARCHIBALD RADDVPKPBRM: Copper sulfate method for measuring specific gravities of whole blood and plasma, Bumed News Letter, 1943, l, No. 9; Bull. U. S. Army Med. Dept., 1943, lxxi, 66. Publications of the Josiah Macy Jr. Foundation, 1945. Google Scholar36. SELLARDS AW: The relationship of renal lesions of Asiatic cholera to those of ordinary nephritis, Am. Jr. Trop. Dis., 1914-15, ii, 104. Google Scholar37. WIGGERSINGRAHAM JCRC: Continuous intravenous infusion of alkalinizing agents during impending hemorrhagic shock conditions, Fed. Proc., 1946, Part II, v, 113. Google Scholar38. PALMERVAN SLYKE WWDD: Studies of acidosis. IX. Relationship between alkali retention and alkali reserve in normal and pathological individuals, Jr. Biol. Chem., 1917, xxxii, 499. CrossrefGoogle Scholar39. MARTINWERKMAN HEM: Serum potassium, magnesium, and calcium levels in diabetic acidosis, Jr. Clin. Invest., 1947, xxvi, 217. CrossrefGoogle Scholar40. HARTMANN AF: Theory and practice of parenteral fluid administration, Jr. Am. Med. Assoc., 1934, ciii, 1349. CrossrefGoogle Scholar41. KOLFF WJ: Personal communication. Google Scholar42. KOLFF WJ: The artificial kidney, Press of J. J. Kok N. V. Kampen (Holland), 1946. Google Scholar43. KOLFFBERK WJHR: The artificial kidney: a dialyzer with great area, Acta med. Scandin., 1944, cxvii, 121. Google Scholar44. ABELROWNTREETURNER JJLGBB: On the removal of diffusible substances from the circulating blood of living animals by dialysis, Jr. Pharm. and Exper. Therap., 1913, v, 275. Google Scholar45. FINEFRANKSELIGMAN JHAAM: The treatment of acute renal failure by peritoneal irrigation, Ann. Surg., 1946, cxxiv, 857. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*From an address given at the Twenty-Eighth Annual Session of the American College of Physicians, Chicago, April 30, 1947.From The Hospital of The Rockefeller Institute for Medical Research, New York 19, New York. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRENAL TUBULAR FAILURE OF SHOCK AND NEPHRITIS*DONALD D. VAN SLYKEACUTE TUBULAR NEPHROSIS, A COMPLICATION OF SHOCK*VIRGIL H. MOON, M.D.THE PROLONGED WATERHOUSE-FRIDERICHSEN SYNDROME WITH RENAL AND MYOCARDIAL INSUFFICIENCY*STUART H. WALKER, ROBERT L. CAVENAUGH, HAROLD WILLIAMSPROLONGED RENAL SALT WASTAGE IN "LOWER NEPHRON NEPHROSIS"*RICHARD B. HUNTER, M.D., E. E. MUIRHEAD, M.D.MYOCARDIAL INVOLVEMENT IN ACUTE NONSPECIFIC PERICARDITIS: A REPORT OF THREE CASES*JOHN GODFREY, M.D.RENAL ANOXIA SYNDROME: A REVIEW AND REPORT OF 22 CASES*PETER GABERMAN, M.D., DONALD H. ATLAS, M.D., F.A.C.P., ERWIN M. KAMMERLING, M.D., LEE EHRLICH, M.D., JULIEN ISAACS, M.D.INTRACTABLE HEART FAILURE*SAMUEL PROGER, M.D., JOSEPH J. O'CONNOR, M.D.THE QUESTION OF TRAUMATIC HEART DISEASE*IRA GORE, M.D. 1 April 1948Volume 28, Issue 4Page: 701-722KeywordsAcute renal failure Issue Published: 1 April 1948 Copyright & PermissionsCopyright, 1948, by The American College of PhysiciansPDF downloadLoading ...