Comparative Purification of Myocardial Myosin and Antigenic Specificity of the Two Light Chains

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Population

Dog myocardial myosin preparations

Design

Preclinical

Authors

Discussion

Provides canine myosin model for light chain studies; leaves open human translation.

Population

Dog myocardial myosin preparations

Intervention

Purification procedures utilizing one or two (NH4)2SO4 fractionations, urea denaturation, and column chromatography

Outcome

Purity of myosin preparations, myosin ATPase activity, and antigenic specificity of light chainssurrogate

The study demonstrates a method for purifying dog myocardial myosin and establishes the antigenic specificity of its two light chains.

Wikman‐Coffelt et al. (1973) studied this question.

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