Why the study?
Does measurement of Pregnancy-specific beta 1-glycoprotein (SP1) levels predict the outcome of pregnancy in women with vaginal bleeding in the first half of pregnancy?
Does measurement of Pregnancy-specific beta 1-glycoprotein (SP1) levels predict the outcome of pregnancy in women with vaginal bleeding in the first half of pregnancy?
Low SP1 levels measured by nephelometry invariably predict spontaneous abortion in women presenting with vaginal bleeding in the first half of pregnancy.
Low SP1 may predict abortion in first-trimester bleeding; hypothesis-generating and requires prospective validation before clinical use.
Pregnancy-specific beta 1-glycoprotein (SP1) levels were measured by nephelometry in sera from 107 women admitted to hospital because of vaginal bleeding in weeks 8 to 20 of pregnancy. The SP1 results were compared with those in single samples from 655 women and serial samples from 9 women with uncomplicated single pregnancies in the same period. The possibility of predicting the outcome of a pregnancy complicated by vaginal bleeding was calculated on the basis of the SP1 level on admission to hospital. In 65% a normal SP1 value predicted continuation of pregnancy, whereas a low SP1 value invariably predicted spontaneous abortion.
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L. Tamsen (1984) studied this question.
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