Soluble guanylyl cyclase (sGC), the key transducer of nitric oxide (NO) signalling in vascular smooth muscle cells and platelets, exists in two redox forms: the NO-sensitive ferrous heme-iron (Fe(II)) form and a NO-insensitive oxidized form containing the ferric heme-iron (Fe(III)). HMR1766 (proposed INN ataciguat sodium) reversibly stimulates the oxidized form of sGC (crude and purified) in various species and organs to about 10 to 30 % of the maximal activity achieved with NO donors. Acute treatment with HMR1766 has anti-ischemic (acute coronary stenosis) and anti-thrombotic (coronary thrombosis) effects in dog models at doses that did not influence arterial blood pressure or other hemodynamic parameters.
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Schindler et al. (2005) studied this question.