Why the study?
Does anesthesia with isoflurane alter ventricular filling velocities in racing pigeons?
Does anesthesia with isoflurane alter ventricular filling velocities in racing pigeons?
Isoflurane anesthesia significantly alters diastolic filling velocities and induces left atrioventricular valve insufficiency in racing pigeons, highlighting the importance of myocardial contraction for normal valve function.
Isoflurane confounds avian echocardiographic diastolic assessments; leaves open generalization to other species or clinical settings.
= 43) are evaluated by pulsed-wave (PW) Doppler sonography. Sonographic examination demonstrates an early passive ventricular (E wave) and late active (A wave) ventricular filling. The results indicate differences between the two heart ventricles. Especially, the E wave velocity of the right heart is significantly lower than in the left heart, which is explained by the crescent-shaped cavity of the right ventricle around the left ventricle. The faster active filling velocities are significantly influenced by heart rate in conscious birds. Anesthesia with isoflurane leads to a significant decrease of the diastolic blood flow velocities, and the A wave velocities of both ventricles are especially influenced. Anesthesia with isoflurane induces a high incidence of insufficiencies of the left atrioventricular valve in the preejection period. These observations indicate that a contraction of the left ventricle myocardium is important for a complete valvular closure and for normal functioning of this heart valve. The effective closure of the right atrioventricular muscle valve in anesthetized pigeons supports the observation of the fast innervation of this muscle valve via a direct connection to the right atrium.
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Legler et al. (2019) studied this question.
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