Answers are grounded in this paper and cite their sources.
The currently used tuberculosis (TB) vaccine (Bacillus Calmette-Guérin) does not consistently prevent pulmonary infection. Novel vaccine strategies require an in-depth characterization of the cellular and molecular mechanisms of antituberculous protection. This review summarizes relevant data obtained in animal models of TB infection. In mycobacterial infections, immunologically mediated protection is intrinsically associated with tissue damage in the form of granuloma formation. The implications of this finding for future vaccine design and evaluation are discussed.
No takes yet. Share an insight, caveat, or question.
Stefan Ehlers (1999) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: