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September 23, 2008Journal of Vascular Research

Vascular Pharmacology of ATP-Sensitive K + Channels: Interactions between Glyburide and K + Channel Openers

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Population

Isolated rabbit superior mesenteric artery (RMA) precontracted with norepinephrine (5 microM)

Comparison

Glyburide and potassium channel openers vs Charybdotoxin, glipizide, or varying pH conditions

Design

Preclinical

Authors

KMKaushik D. MeisheriIdaho State UniversitySKSajida KhanYale UniversityJMJami L. Martin

Discussion

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Overview

Glyburide's vascular KATP blockade in animal models should not alter clinical practice; leaves open translation of pH-dependent mechanisms to human vessels.

Structured PICO

P
Population
Isolated rabbit superior mesenteric artery (RMA) precontracted with norepinephrine (5 microM)
I
Intervention
Glyburide (10-500 nM) and potassium channel openers (minoxidil sulfate, pinacidil, cromakalim, RP-49356)
C
Comparator
Charybdotoxin (200 nM), glipizide, or varying pH conditions (6.4 vs. 7.3)
O
Outcome
Inhibition of the potassium channel opener-induced relaxation time course and maximum relaxationsurrogate

Glyburide effectively blocks the vascular relaxation induced by diverse potassium channel openers, suggesting a shared mechanism of KATP channel activation that is highly pH-dependent.

Cite This Study

Meisheri et al. (2008) studied this question.

synapsesocial.com/papers/6a8545109df997f4bbd6a4behttps://doi.org/10.1159/000158969
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Effects of Potassium Channel Openers and Blockers on the Specific Binding Sites for [3H]Glibenclamide in Rat Tissues1995 · 4 citations
  2. 2Glyburide Actions on the Dihydropyridine-Sensitive Ca 2+ Channel in Rat Vascular Muscle2008 · 14 citations
  3. 3Renal and Vascular Effects of Chemically Distinct ATP-Sensitive K+ Channel Blockers in Rats1995 · 13 citations
  4. 4Comparative Effects of the Potassium Channel Openers Cromakalim and Pinacidil and the Cromakalim Analog U-89232 on Isolated Vascular and Cardiac Tissue2008 · 13 citations
  5. 5Pharmacology of ATP-sensitive K+ currents in smooth muscle cells from rabbit mesenteric artery1995 · 91 citations