Controlled and sustained delivery of drugs for ophthalmic diseases continues to remain a major challenge in the field of pharmaceutical drug delivery. To overcome the problems of conventional ocular therapy, such as short residence time, drug drainage and frequent instillation, newer drug-delivery systems are being explored to improve the ocular bioavailability of the drug. In this review, research concerning nanoparticles for topical drug delivery is discussed. We highlight cutting-edge drug-delivery nanotechnologies that improve the efficacy of current drug-delivery methods or ameliorate the delivery of novel therapeutics.
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Bucolo et al. (2008) studied this question.
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