High Intra-abdominal Pressure Increases Plasma Catecholamine Concentrations During Pneumoperitoneum for Laparoscopic Procedures

Background: Laparoscopic procedures are associated with several complications, such as hemodynamic, respiratory, and endocrine complications.In our previous clinical study, plasma epinephrine and norepinephrine concentrations remained unchanged after the insertion of a Veress needle, but increased significantly immediately after insufflation with carbon dioxide into the peritoneum.The mechanisms for this increase are unknown.Objective: To investigate whether gas insufflation during pneumoperitoneum affects plasma catecholamine concentrations during laparoscopic procedures.Design: Experimental study in pigs. Main Outcome Measures:The plasma concentrations of epinephrine and norepinephrine were measured in the pigs before and after pneumoperitoneum.The mean arterial pressure, heart rate, cardiac output, and arterial blood gas levels were measured, and the systemic vascular resistance was calculated.Intervention: Air, nitrous oxide