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February 18, 2008European Journal of Inorganic Chemistry

Isolation of an Intermediate in the Platination of p‐Nitroacetophenone 4‐Methylthiosemicarbazone: Potential Application as an Antitumor Drug

Adoración G. Quiroga Leticia Cubo Pablo J. Sanz Miguel Victoria Moneo Amancio Carnero Carmen Navarro‐Ranninger

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Abstract

The investigation of the formation and reactivity of Pd and Pt thiosemicarbazone complexes has revealed an unstudied intermediate derived from p ‐nitroacetophenone 4‐methylthiosemicabazone (L1H 2 ). The L1H 2 ligand leads to a new complex [Pt(L1)(L1H 2 )] that supports the postulated mechanism of how cyclometallation reactions take place. All the newly synthesized complexes, [(Pd(L1) 4 ], [(Pt(L1) 4 ], and [Pt(L1)(L1H 2 )] ( 3 ), have been characterized and tested against MCF7, SF268, and NCI H460 cell lines. The crystal structure of [Pt(L1)(L1H 2 )] · dmso is reported. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

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Quiroga et al. (2008) studied this question.

synapsesocial.com/papers/6a854826e977d9a03fc6b022 https://doi.org/10.1002/ejic.200800003

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