Experimental Nephrotic Syndrome Induced in Rats by Aminonucleoside. Renal Lesions and Body Electrolyte Composition.

The nephrotic syndrome was regularly induced in immature male rats by 12 daily injections of an aminonucleoside. The essential renal lesions were thickening of the glomerular basement membranes and loss of mitochondria in renal convoluted tubular cells. Electrolyte composition of serum, ascitic fluid, muscle, entire skin, and carcass also was determined. Suitable corrections for collagen were used where applicable. Skin was shown to be the major tissue reservoir for accumulation of edema fluid.