This preclinical study elucidates the complex neuroeffector mechanisms, including purinergic and adrenergic pathways, regulating arterial tone in canine splenic arteries.
No immediate clinical implications; leaves open translation of canine splenic artery co-transmission to human vascular physiology.
It has been recognized that sympathetic neurons release several transmitters but mainly adenosine 5'-triphosphate (ATP), noradrenaline, and neuropeptide Y (NPY). Recently, we reported that periarterial nerve electrical stimulation (PNS) produced biphasic vasoconstrictions consisting of an initial transient, predominantly P2X-purinoceptor-mediated constriction followed by a prolonged, alpha(1)-adrenoceptor-mediated one in canine isolated splenic arteries. In this article, we tried to analyze the effects of several selective key drugs that influence the PNS-induced responses, and we functionally showed sympathetic transmitter releasing mechanisms by pharmacological analysis using purinergic, adrenergic, and NPYergic agonists and antagonists.
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Chiba et al. (2003) studied this question.
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