In conscious rabbits, changes in blood pressure in response to carotid sinus pressure changes are primarily driven by systemic vascular resistance rather than cardiac output, except immediately during a depressor response.
SVR dominates baroreflex BP control in rabbits except early depressor phase; leaves open translation to human autonomic therapies.
This paper reports experiments to determine the relative roles of changes in cardiac output and systemic vascular resistance in determining the blood pressure response to intermittent step-changes and continuous sinusoidal changes in carotid sinus transmural pressure. Conscious rabbits with a variable-pressure capsule implanted around an innervated carotid sinus were used. After step-change in capsule pressure the approximate proportions of the changes in blood pressure attributable to changes in cardiac output were, during the pressor response, 7% after 2.5 s, 22% after 10 s and 27% at plateau, and during the depressor response 100%, 8% and 17%, respectively. During sinusoidal change in capsule pressure a mean 7% of the change in blood pressure over the full cycle was attributable to change in cardiac output.
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Faris et al. (1981) studied this question.
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