At low substrate concentrations linoleate oxidation isolated rat-liver mitochondria can be stimulated by of phosphate and phosphate acceptor. ADP as phosphate acceptor this State-3 linoleate is strongly inhibited after addition of CoASH. by CoASH itself seems rather unlikely. However, media containing ADP and Mg²+ the longchain -CoA synthetase present in the outer mitochondrial can form linoleyl-CoA, being derived from ADP through the action of kinase.
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Vaartjes et al. (1972) studied this question.
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