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April 1, 2000The FASEB Journal

Transgenic mouse models for studying the functions of insulin‐like growth factor‐binding proteins

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Population

Transgenic mouse models overexpressing IGFBP-1, -2, -3, or -4

Design

Review

Authors

MSMarlon R. SchneiderHLHarald LahmMWMinyao Wu

Discussion

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Overview

These mouse phenotypes warrant no clinical action; extends evidence for distinct IGFBP tissue roles requiring human validation.

Structured PICO

P
Population
Transgenic mouse models overexpressing IGFBP-1, -2, -3, or -4
I
Intervention
Overexpression of insulin-like growth factor-binding proteins (IGFBP-1, -2, -3, or -4)
O
Outcome
Phenotypic alterations resulting from IGFBP overexpressionsurrogate

Transgenic mouse models reveal that different insulin-like growth factor-binding proteins have distinct, tissue-specific functions in vivo.

Cite This Study

Schneider et al. (2000) studied this question.

synapsesocial.com/papers/6a855aa09df929a58fad97b0https://doi.org/10.1096/fasebj.14.5.629
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Islet cell proliferation and apoptosis in insulin-like growth factor binding protein-1 in transgenic mice1997 · 18 citations
  2. 2Alteration in Pancreatic Immunoreactivity of Insulin-Like Growth Factor (IGF)-Binding Protein (IGFBP)-6 and in Intracellular Degradation of IGFBP-3 in Fibroblasts of IGF-II Receptor/IGF-II-Deficient Mice1999 · 17 citations
  3. 3Insulin‐like growth factor‐binding protein‐2 inhibits proliferation of human embryonic kidney fibroblasts and of IGF‐responsive colon carcinoma cell lines1998 · 76 citations