Why the study?
Can a 2D Fluid-Structure Interaction model estimate maximum pressure in the left ventricle based on cardiac outputs at rest and during exercise?
Can a 2D Fluid-Structure Interaction model estimate maximum pressure in the left ventricle based on cardiac outputs at rest and during exercise?
The study proposes a 2D Fluid-Structure Interaction model to estimate maximum left ventricular pressure using non-invasive and invasive cardiac output measurements at rest and during exercise.
Model may enable non-invasive peak LV pressure estimation during exercise; leaves open prospective clinical validation before any use.
Aims: Study of maximum pressure in the left ventricle (MPLV) has already been a challenging aspect of clinical diagnosis. The aim of this study was to propose a model to estimate the MPLV for a healthy subject based on cardiac outputs measured by echo-Doppler (non-invasive) and catheterization (invasive) techniques at rest and during exercise. Study Design and Methodology: Blood flow through the aortic valve was measured by Doppler flow echocardiography. The aortic valve geometry was then calculated by echocardiographic imaging. A Fluid-Structure Interaction (FSI) simulation was performed, using an Arbitrary Lagrangian-Eulerian (ALE) mesh. Boundary conditions were defined as pressure loads on ventricular and aortic sides during ejection phase. The FSI modelling was applied to determine a numerical relationship between the cardiac output to left
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Arezoo Khosravi (2014) studied this question.
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